heroes holding hands

COMET — a study for low-risk DCIS:
expanding knowledge and options.

Learn More

Scale

COMET stands for Comparing an Operation to Monitoring, with or without Endocrine Therapy, for low-risk DCIS.

Map

The COMET Study is being conducted across the United States to compare two treatment approaches for low-risk DCIS: Active Monitoring and Surgery.

Couple

The COMET study is needed because these treatment approaches have not been compared directly before in patients with low-risk DCIS.

Our Research

The COMET Study enrolled 995 women with low-risk DCIS at 100 sites throughout the US.

In December 2024, the initial (2-year) results of the COMET Study (clinical and patient-reported outcomes) were presented at the San Antonio Breast Cancer Symposium and published in Journal of the American Medical Association (JAMA) and JAMA Oncology! Please click on the links below to see these exciting results!

Active Monitoring With or Without Endocrine Therapy for Low-Risk Ductal Carcinoma In Situ: The COMET Randomized Clinical Trial (JAMA)

Patient-Reported Outcomes for Low-Risk Ductal Carcinoma In Situ: A Secondary Analysis of the COMET Randomized Clinical Trial (JAMA Oncology)

Home Research Doctor

COMET Study Team

Shelley Hwang

Shelley Hwang
Principal Investigator

Ann Partridge

Ann Partridge
Co-Principal Investigator

Alastair Thompson

Alastair Thompson
Co-Principal Investigator

Elizabeth Frank

Elizabeth Frank
Lead Patient Advocate

Deborah Collyar

Deborah Collyar
Patient Advocate

Donna Pinto

Donna Pinto
Patient Advocate

Desiree Basila

Desiree Basila
Patient Advocate

Terry Hyslop

Terry Hyslop
Statistician

Thomas Lynch

Thomas Lynch
Project Manager

Supporters

Patient-Centered Outcomes Research Institute
Alliance Foundation Trials
Breast Cancer Research Foundation
Rising Tide
Duke Health
Dana-Farber Cancer Institute
Baylor College of Medicine
Cancer Research Program
National Cancer Database
Quintet